TY - JOUR AU - Rosa, D. D. AU - Ismael, G. AU - Lago, L. D. AU - Awada, A. PY - 2008 DA - 2008// TI - Molecular-targeted therapies: lessons from years of clinical development JO - Cancer Treat Rev VL - 34 UR - https://doi.org/10.1016/j.ctrv.2007.07.019 DO - 10.1016/j.ctrv.2007.07.019 ID - Rosa2008 ER - TY - JOUR AU - Cusack, J. C. PY - 2003 DA - 2003// TI - Overcoming antiapoptotic responses to promote chemosensitivity in metastatic colorectal cancer to the liver JO - Ann Surg Oncol VL - 10 UR - https://doi.org/10.1245/ASO.2003.07.518 DO - 10.1245/ASO.2003.07.518 ID - Cusack2003 ER - TY - JOUR AU - Sorscher, S. M. PY - 2007 DA - 2007// TI - Biological therapy update in colorectal cancer JO - Expert Opin Biol Ther VL - 7 UR - https://doi.org/10.1517/14712598.7.4.509 DO - 10.1517/14712598.7.4.509 ID - Sorscher2007 ER - TY - JOUR AU - Mimeault, M. AU - Batra, S. K. PY - 2010 DA - 2010// TI - Novel therapies against aggressive and recurrent epithelial cancers by molecular targeting tumor- and metastasis-initiating cells and their progenies JO - Anticancer Agents Med Chem VL - 10 UR - https://doi.org/10.2174/187152010790909353 DO - 10.2174/187152010790909353 ID - Mimeault2010 ER - TY - JOUR AU - Rudmik, L. R. AU - Magliocco, A. M. PY - 2005 DA - 2005// TI - Molecular mechanisms of hepatic metastasis in colorectal cancer JO - J Surg Oncol VL - 92 UR - https://doi.org/10.1002/jso.20393 DO - 10.1002/jso.20393 ID - Rudmik2005 ER - TY - JOUR AU - Merino, D. AU - Lalaoui, N. AU - Morizot, A. AU - Solary, E. AU - Micheau, O. PY - 2007 DA - 2007// TI - TRAIL in cancer therapy: present and future challenges JO - Expert Opin Ther Targets VL - 11 UR - https://doi.org/10.1517/14728222.11.10.1299 DO - 10.1517/14728222.11.10.1299 ID - Merino2007 ER - TY - JOUR AU - Rowinsky, E. K. PY - 2005 DA - 2005// TI - Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agents JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.02.2889 DO - 10.1200/JCO.2005.02.2889 ID - Rowinsky2005 ER - TY - JOUR AU - Kruyt, F. A. PY - 2008 DA - 2008// TI - TRAIL and cancer therapy JO - Cancer Lett VL - 263 UR - https://doi.org/10.1016/j.canlet.2008.02.003 DO - 10.1016/j.canlet.2008.02.003 ID - Kruyt2008 ER - TY - JOUR AU - Fernandez, T. AU - Torres, M. J. AU - R, R. P. AU - Fuentes, M. S. AU - Robles, S. AU - Mayorga, C. AU - Blanca, M. PY - 2005 DA - 2005// TI - Decrease of selective immunoglobulin E response to amoxicillin despite repeated administration of benzylpenicillin and penicillin V JO - Clin Exp Allergy VL - 35 UR - https://doi.org/10.1111/j.1365-2222.2005.02378.x DO - 10.1111/j.1365-2222.2005.02378.x ID - Fernandez2005 ER - TY - JOUR AU - Nieminen, A. I. AU - Partanen, J. I. AU - Klefstrom, J. PY - 2007 DA - 2007// TI - c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc JO - Cell Cycle VL - 6 UR - https://doi.org/10.4161/cc.6.20.4917 DO - 10.4161/cc.6.20.4917 ID - Nieminen2007 ER - TY - JOUR AU - Hoffman, B. AU - Liebermann, D. A. PY - 2008 DA - 2008// TI - Apoptotic signaling by c-MYC JO - Oncogene VL - 27 UR - https://doi.org/10.1038/onc.2008.312 DO - 10.1038/onc.2008.312 ID - Hoffman2008 ER - TY - JOUR AU - Nieminen, A. I. AU - Partanen, J. I. AU - Hau, A. AU - Klefstrom, J. PY - 2007 DA - 2007// TI - c-Myc primed mitochondria determine cellular sensitivity to TRAIL-induced apoptosis JO - EMBO J VL - 26 UR - https://doi.org/10.1038/sj.emboj.7601551 DO - 10.1038/sj.emboj.7601551 ID - Nieminen2007 ER - TY - JOUR AU - Wang, Y. AU - Engels, I. H. AU - Knee, D. A. AU - Nasoff, M. AU - Deveraux, Q. L. AU - Quon, K. C. PY - 2004 DA - 2004// TI - Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway JO - Cancer Cell VL - 5 UR - https://doi.org/10.1016/S1535-6108(04)00113-8 DO - 10.1016/S1535-6108(04)00113-8 ID - Wang2004 ER - TY - JOUR AU - Um, J. H. AU - Kwon, J. K. AU - Kang, C. D. AU - Kim, M. J. AU - Ju, D. S. AU - Bae, J. H. AU - Kim, D. W. AU - Chung, B. S. AU - Kim, S. H. PY - 2004 DA - 2004// TI - Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade JO - J Pharmacol Exp Ther VL - 311 UR - https://doi.org/10.1124/jpet.104.070938 DO - 10.1124/jpet.104.070938 ID - Um2004 ER - TY - JOUR AU - An, J. AU - Yang, D. Y. AU - Xu, Q. Z. AU - Zhang, S. M. AU - Huo, Y. Y. AU - Shang, Z. F. AU - Wang, Y. AU - Wu, D. C. AU - Zhou, P. K. PY - 2008 DA - 2008// TI - DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein JO - Mol Cancer VL - 7 UR - https://doi.org/10.1186/1476-4598-7-32 DO - 10.1186/1476-4598-7-32 ID - An2008 ER - TY - JOUR AU - Qiao, M. AU - Iglehart, J. D. AU - Pardee, A. B. PY - 2007 DA - 2007// TI - Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-07-0877 DO - 10.1158/0008-5472.CAN-07-0877 ID - Qiao2007 ER - TY - JOUR AU - Kim, S. H. AU - Ricci, M. S. AU - El-Deiry, W. S. PY - 2008 DA - 2008// TI - Mcl-1: a gateway to TRAIL sensitization JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-6278 DO - 10.1158/0008-5472.CAN-07-6278 ID - Kim2008 ER - TY - JOUR AU - Ricci, M. S. AU - Kim, S. H. AU - Ogi, K. AU - Plastaras, J. P. AU - Ling, J. AU - Wang, W. AU - Jin, Z. AU - Liu, Y. Y. AU - Dicker, D. T. AU - Chiao, P. J. PY - 2007 DA - 2007// TI - Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death JO - Cancer Cell VL - 12 UR - https://doi.org/10.1016/j.ccr.2007.05.006 DO - 10.1016/j.ccr.2007.05.006 ID - Ricci2007 ER - TY - JOUR AU - Ricci, M. S. AU - Jin, Z. AU - Dews, M. AU - Yu, D. AU - Thomas-Tikhonenko, A. AU - Dicker, D. T. AU - El-Deiry, W. S. PY - 2004 DA - 2004// TI - Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity JO - Mol Cell Biol VL - 24 UR - https://doi.org/10.1128/MCB.24.19.8541-8555.2004 DO - 10.1128/MCB.24.19.8541-8555.2004 ID - Ricci2004 ER - TY - JOUR AU - Iijima, S. AU - Teraoka, H. AU - Date, T. AU - Tsukada, K. PY - 1992 DA - 1992// TI - DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein JO - Eur J Biochem VL - 206 UR - https://doi.org/10.1111/j.1432-1033.1992.tb16964.x DO - 10.1111/j.1432-1033.1992.tb16964.x ID - Iijima1992 ER - TY - JOUR AU - Lane, D. AU - Robert, V. AU - Grondin, R. AU - Rancourt, C. AU - Piche, A. PY - 2007 DA - 2007// TI - Malignant ascites protect against TRAIL-induced apoptosis by activating the PI3K/Akt pathway in human ovarian carcinoma cells JO - Int J Cancer VL - 121 UR - https://doi.org/10.1002/ijc.22840 DO - 10.1002/ijc.22840 ID - Lane2007 ER - TY - JOUR AU - Larribere, L. AU - Khaled, M. AU - Tartare-Deckert, S. AU - Busca, R. AU - Luciano, F. AU - Bille, K. AU - Valony, G. AU - Eychene, A. AU - Auberger, P. AU - Ortonne, J. P. PY - 2004 DA - 2004// TI - PI3K mediates protection against TRAIL-induced apoptosis in primary human melanocytes JO - Cell Death Differ VL - 11 UR - https://doi.org/10.1038/sj.cdd.4401475 DO - 10.1038/sj.cdd.4401475 ID - Larribere2004 ER - TY - JOUR AU - Asakuma, J. AU - Sumitomo, M. AU - Asano, T. AU - Hayakawa, M. PY - 2003 DA - 2003// TI - Selective Akt inactivation and tumor necrosis actor-related apoptosis-inducing ligand sensitization of renal cancer cells by low concentrations of paclitaxel JO - Cancer Res VL - 63 ID - Asakuma2003 ER - TY - JOUR AU - Xu, J. AU - Zhou, J. Y. AU - Wei, W. Z. AU - Wu, G. S. PY - 2010 DA - 2010// TI - Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells JO - PLoS One VL - 5 UR - https://doi.org/10.1371/journal.pone.0010226 DO - 10.1371/journal.pone.0010226 ID - Xu2010 ER - TY - JOUR AU - Feng, J. AU - Park, J. AU - Cron, P. AU - Hess, D. AU - Hemmings, B. A. PY - 2004 DA - 2004// TI - Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M406731200 DO - 10.1074/jbc.M406731200 ID - Feng2004 ER - TY - JOUR AU - Teraoka, H. AU - Yumoto, Y. AU - Watanabe, F. AU - Tsukada, K. AU - Suwa, A. AU - Enari, M. AU - Nagata, S. PY - 1996 DA - 1996// TI - CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme JO - FEBS Lett VL - 393 UR - https://doi.org/10.1016/0014-5793(96)00842-3 DO - 10.1016/0014-5793(96)00842-3 ID - Teraoka1996 ER - TY - JOUR AU - Durant, S. AU - Karran, P. PY - 2003 DA - 2003// TI - Vanillins--a novel family of DNA-PK inhibitors JO - Nucleic Acids Res VL - 31 UR - https://doi.org/10.1093/nar/gkg753 DO - 10.1093/nar/gkg753 ID - Durant2003 ER - TY - JOUR AU - Seo, S. B. AU - Hur, J. G. AU - Kim, M. J. AU - Lee, J. W. AU - Kim, H. B. AU - Bae, J. H. AU - Kim, D. W. AU - Kang, C. D. AU - Kim, S. H. PY - 2010 DA - 2010// TI - TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases JO - Mol Cancer VL - 9 UR - https://doi.org/10.1186/1476-4598-9-199 DO - 10.1186/1476-4598-9-199 ID - Seo2010 ER - TY - JOUR AU - Park, S. J. AU - Bijangi-Vishehsaraei, K. AU - Safa, A. R. PY - 2010 DA - 2010// TI - Selective TRAIL-triggered apoptosis due to overexpression of TRAIL death receptor 5 (DR5) in P-glycoprotein-bearing multidrug resistant CEM/VBL1000 human leukemia cells JO - Int J Biochem Mol Biol VL - 1 ID - Park2010 ER - TY - JOUR AU - Hall, M. A. AU - Cleveland, J. L. PY - 2007 DA - 2007// TI - Clearing the TRAIL for Cancer Therapy JO - Cancer Cell VL - 12 UR - https://doi.org/10.1016/j.ccr.2007.06.011 DO - 10.1016/j.ccr.2007.06.011 ID - Hall2007 ER - TY - JOUR AU - Pelengaris, S. AU - Khan, M. AU - Evan, G. PY - 2002 DA - 2002// TI - c-MYC: more than just a matter of life and death JO - Nat Rev Cancer VL - 2 UR - https://doi.org/10.1038/nrc904 DO - 10.1038/nrc904 ID - Pelengaris2002 ER - TY - JOUR AU - Hueber, A. O. AU - Zornig, M. AU - Lyon, D. AU - Suda, T. AU - Nagata, S. AU - Evan, G. I. PY - 1997 DA - 1997// TI - Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis JO - Science VL - 278 UR - https://doi.org/10.1126/science.278.5341.1305 DO - 10.1126/science.278.5341.1305 ID - Hueber1997 ER - TY - JOUR AU - Klefstrom, J. AU - Arighi, E. AU - Littlewood, T. AU - Jaattela, M. AU - Saksela, E. AU - Evan, G. I. AU - Alitalo, K. PY - 1997 DA - 1997// TI - Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation JO - EMBO J VL - 16 UR - https://doi.org/10.1093/emboj/16.24.7382 DO - 10.1093/emboj/16.24.7382 ID - Klefstrom1997 ER - TY - JOUR AU - Han, J. AU - Goldstein, L. A. AU - Gastman, B. R. AU - Rabinowich, H. PY - 2006 DA - 2006// TI - Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M510349200 DO - 10.1074/jbc.M510349200 ID - Han2006 ER - TY - JOUR AU - Kataoka, T. AU - Tschopp, J. PY - 2004 DA - 2004// TI - N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway JO - Mol Cell Biol VL - 24 UR - https://doi.org/10.1128/MCB.24.7.2627-2636.2004 DO - 10.1128/MCB.24.7.2627-2636.2004 ID - Kataoka2004 ER - TY - JOUR AU - Shintani, S. AU - Mihara, M. AU - Li, C. AU - Nakahara, Y. AU - Hino, S. AU - Nakashiro, K. AU - Hamakawa, H. PY - 2003 DA - 2003// TI - Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma JO - Cancer Sci VL - 94 UR - https://doi.org/10.1111/j.1349-7006.2003.tb01372.x DO - 10.1111/j.1349-7006.2003.tb01372.x ID - Shintani2003 ER - TY - JOUR AU - Stronati, L. AU - Gensabella, G. AU - Lamberti, C. AU - Barattini, P. AU - Frasca, D. AU - Tanzarella, C. AU - Giacobini, S. AU - Toscano, M. G. AU - Santacroce, C. AU - Danesi, D. T. PY - 2001 DA - 2001// TI - Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma JO - Cancer VL - 92 UR - https://doi.org/3.0.CO;2-7 DO - 3.0.CO;2-7 ID - Stronati2001 ER - TY - JOUR AU - Tonotsuka, N. AU - Hosoi, Y. AU - Miyazaki, S. AU - Miyata, G. AU - Sugawara, K. AU - Mori, T. AU - Ouchi, N. AU - Satomi, S. AU - Matsumoto, Y. AU - Nakagawa, K. PY - 2006 DA - 2006// TI - Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium JO - Int J Mol Med VL - 18 ID - Tonotsuka2006 ER - TY - JOUR AU - Moll, U. AU - Lau, R. AU - Sypes, M. A. AU - Gupta, M. M. AU - Anderson, C. W. PY - 1999 DA - 1999// TI - DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues JO - Oncogene VL - 18 UR - https://doi.org/10.1038/sj.onc.1202640 DO - 10.1038/sj.onc.1202640 ID - Moll1999 ER - TY - JOUR AU - An, J. AU - Xu, Q. Z. AU - Sui, J. L. AU - Bai, B. AU - Zhou, P. K. PY - 2005 DA - 2005// TI - Downregulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells JO - Int J Cancer VL - 117 UR - https://doi.org/10.1002/ijc.21093 DO - 10.1002/ijc.21093 ID - An2005 ER - TY - JOUR AU - Puduvalli, V. K. AU - Sampath, D. AU - Bruner, J. M. AU - Nangia, J. AU - Xu, R. AU - Kyritsis, A. P. PY - 2005 DA - 2005// TI - TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation JO - Apoptosis VL - 10 UR - https://doi.org/10.1007/s10495-005-6078-3 DO - 10.1007/s10495-005-6078-3 ID - Puduvalli2005 ER - TY - JOUR AU - Lee, Y. J. AU - Froelich, C. J. AU - Fujita, N. AU - Tsuruo, T. AU - Kim, J. H. PY - 2004 DA - 2004// TI - Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage JO - Clin Cancer Res VL - 10 UR - https://doi.org/10.1158/1078-0432.CCR-03-0136 DO - 10.1158/1078-0432.CCR-03-0136 ID - Lee2004 ER - TY - JOUR AU - Affar, E. B. AU - Germain, M. AU - Winstall, E. AU - Vodenicharov, M. AU - Shah, R. G. AU - Salvesen, G. S. AU - Poirier, G. G. PY - 2001 DA - 2001// TI - Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis JO - J Biol Chem VL - 276 UR - https://doi.org/10.1074/jbc.M007269200 DO - 10.1074/jbc.M007269200 ID - Affar2001 ER - TY - JOUR AU - Graham, K. L. AU - Gustin, K. E. AU - Rivera, C. AU - Kuyumcu-Martinez, N. M. AU - Choe, S. S. AU - Lloyd, R. E. AU - Sarnow, P. AU - Utz, P. J. PY - 2004 DA - 2004// TI - Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection JO - J Virol VL - 78 UR - https://doi.org/10.1128/JVI.78.12.6313-6321.2004 DO - 10.1128/JVI.78.12.6313-6321.2004 ID - Graham2004 ER - TY - JOUR AU - Kim, S. H. AU - Um, J. H. AU - Dong-Won, B. AU - Kwon, B. H. AU - Kim, D. W. AU - Chung, B. S. AU - Kang, C. D. PY - 2000 DA - 2000// TI - Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin JO - Leuk Res VL - 24 UR - https://doi.org/10.1016/S0145-2126(00)00061-8 DO - 10.1016/S0145-2126(00)00061-8 ID - Kim2000 ER - TY - JOUR AU - Ismail, I. H. AU - Martensson, S. AU - Moshinsky, D. AU - Rice, A. AU - Tang, C. AU - Howlett, A. AU - McMahon, G. AU - Hammarsten, O. PY - 2004 DA - 2004// TI - SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization JO - Oncogene VL - 23 UR - https://doi.org/10.1038/sj.onc.1207303 DO - 10.1038/sj.onc.1207303 ID - Ismail2004 ER - TY - JOUR AU - Zhao, Y. AU - Thomas, H. D. AU - Batey, M. A. AU - Cowell, I. G. AU - Richardson, C. J. AU - Griffin, R. J. AU - Calvert, A. H. AU - Newell, D. R. AU - Smith, G. C. AU - Curtin, N. J. PY - 2006 DA - 2006// TI - Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441 JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-4275 DO - 10.1158/0008-5472.CAN-05-4275 ID - Zhao2006 ER -