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Figure 10 | Molecular Cancer

Figure 10

From: High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde

Figure 10

Effect of DMNB on TRAIL-induced cytotoxicity and apoptosis. PC3 (A) and KM12 (B) cells were treated with the indicated doses of TRAIL in the presence or absence of DMNB (1, 5, or 10 μM), and cell survival was determined after 96 h of incubation using the MTT assay (left). PC3 and KM12 cells were treated with the indicated doses of TRAIL in the presence or absence of 5 μM DMNB for 6 or 8 h, respectively. Thereafter, the percentage of apoptotic cells was determined using Annexin V staining and flow cytometry (right). Each point is the average of triplicate determinants. *p < 0.05, **p < 0.01, ***p < 0.001.

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Molecular Cancer

ISSN: 1476-4598