Figure 2
From: Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and Cyclin-D1 signaling
Immunohistochemistry of primary tumors. (A) A representative serial section of human glioblastoma was stained with hematoxylin and eosin (H&E), white arrows indicate microvascular proliferation, and (B) black arrows indicate anti-LPP3-RGD positive glioblastoma cells. Scale bars, 100 μm. (C) Anti-LPP3 staining in normal pancreas show cytosolic expression in both endocrine (Islet of Langerhans-arrow) and exocrine components. (D, E) In pancreatic endocrine tumors, 65% of the tumors show cytosolic staining. Inset: Nuclear localization of LPP3 is also detected in 40% of cases. (F) An example of LPP3-negative tumor cells. All experiments are representative of those obtained in at least three separate experiments, with similar results.