Figure 1

Structural impact of mutations. The columns show the structural properties of random mutations (Rnd), natural variations (Snp) and cancer mutations (Mut). Cancer mutations are further analyzed separately as mutations of oncogenes (Onc) and mutations of tumor suppressor genes (Sup). The error bars indicate the variability of the data under the jackknife test. The reported values are the odds ratios averaged over the genes in the dataset. The p-values are calculated over all mutations within a dataset. A, observed over expected fraction of mutations occurring at the protein surface. Onc show significantly more and Sup significantly less solvent accessible mutations. B, observed over expected fraction of destabilizing mutations. Onc mutations are less often destabilizing, while Sup mutations disrupt stability far more often than the controls. C, observed over expected functional site mutations. Functional sites are more frequently mutated in Onc than in Sup. D, observed over expected spatial clustering of mutations. Mutations particularly in Onc are significantly more clustered than expected by chance.