From: The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors
Gene name | Length (AA) | Mut | SNP | PDB codes (sequence range) |
---|---|---|---|---|
Oncogenes | Â | Â | Â | Â |
AKT1 | 478 | 6 | 5 | 1UNQA (1-123), 3CQWA (144-480) |
BRAF | 766 | 46 | 3 | 3D4QA (433-726), 3NY5A (153-237) |
EGFR | 1210 | 224 | 9 | 1YY9A (25-642), 1XKKA (695-1022) |
GNAS | 394 | 12 | 9 | 1AZSC (1-394) |
HRAS | 189 | 19 | 0 | 4Q21A (1-189) |
KIT | 976 | 9 | 9 | 2EC8A (1-519), 3G0EA (544-935) |
KRAS | 188 | 85 | 1 | 3GFTA (1-164) |
MET | 1408 | 24 | 30 | 2UZXB (25-740), 3DKCA (1049-1360) |
NRAS | 189 | 9 | 1 | 3CONA (1-172) |
PIK3CA | 1068 | 148 | 17 | 2RD0A (1-1068) |
PTPN11 | 593 | 7 | 6 | 2SHPA (3-529) |
RET | 1114 | 24 | 3 | 2IVSA (705-1013), 2X2UA (29-270) |
Tumor Suppressor Genes | Â | Â | Â | |
CDH1 | 882 | 17 | 3 | 2O72A (155-367) |
CDKN2A | 156 | 76 | 10 | 1BI7B (1-156) |
FBXW7 | 707 | 34 | 4 | 2OVRB (263-707) |
MLH1 | 756 | 8 | 3 | 3NA3A (1-347) |
MSH2 | 934 | 12 | 17 | 2O8BA (1-934) |
PTEN | 403 | 93 | 2 | 1D5RA (8-353) |
RB1 | 928 | 7 | 9 | 2R7GA (380-787), 2QDJA (52-355), 2AZEC (829-874) |
SMAD4 | 552 | 51 | 3 | 1DD1A (285-552) |
STK11 | 433 | 30 | 1 | 2WTKC (43-347) |
TP53 | 393 | 826 | 17 | 2VUKA (94-312), 1AIEA (326-356) |
VHL | 213 | 216 | 16 | 1LM8V (54-213) |
WT1 | 449 | 9 | 3 | 2PRTA (318-438) |