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Table 1 Overview of genes

From: The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors

Gene name

Length (AA)

Mut

SNP

PDB codes (sequence range)

Oncogenes

    

AKT1

478

6

5

1UNQA (1-123), 3CQWA (144-480)

BRAF

766

46

3

3D4QA (433-726), 3NY5A (153-237)

EGFR

1210

224

9

1YY9A (25-642), 1XKKA (695-1022)

GNAS

394

12

9

1AZSC (1-394)

HRAS

189

19

0

4Q21A (1-189)

KIT

976

9

9

2EC8A (1-519), 3G0EA (544-935)

KRAS

188

85

1

3GFTA (1-164)

MET

1408

24

30

2UZXB (25-740), 3DKCA (1049-1360)

NRAS

189

9

1

3CONA (1-172)

PIK3CA

1068

148

17

2RD0A (1-1068)

PTPN11

593

7

6

2SHPA (3-529)

RET

1114

24

3

2IVSA (705-1013), 2X2UA (29-270)

Tumor Suppressor Genes

   

CDH1

882

17

3

2O72A (155-367)

CDKN2A

156

76

10

1BI7B (1-156)

FBXW7

707

34

4

2OVRB (263-707)

MLH1

756

8

3

3NA3A (1-347)

MSH2

934

12

17

2O8BA (1-934)

PTEN

403

93

2

1D5RA (8-353)

RB1

928

7

9

2R7GA (380-787), 2QDJA (52-355), 2AZEC (829-874)

SMAD4

552

51

3

1DD1A (285-552)

STK11

433

30

1

2WTKC (43-347)

TP53

393

826

17

2VUKA (94-312), 1AIEA (326-356)

VHL

213

216

16

1LM8V (54-213)

WT1

449

9

3

2PRTA (318-438)

  1. Abbreviations: AA, amino acid, Mut, number of mutations, SNP, number of SNPs, PDB, Protein Data Bank