Figure 7From: miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent mannerSynergistic action on cell cycle arrest is due to the down-regulation of unique mRNA targets. A549 (A) or H1299 cells (B) were co-transfected with 20 nM miRNA precursors and 7.8 nM siRNA against CCNE1 and subsequently treated for 18 h with nocodazole beginning 24 h post-transfection. Comparable results were also obtained 48 h post-transfection (data not shown).Back to article page