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Figure 4 | Molecular Cancer

Figure 4

From: LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells

Figure 4

Expression analysis of LIMK1 and MT1-MMP in clinical specimens. A) Very low to no staining (black arrows) of LIMK1 and MT1-MMP in luminal cells and weak (red arrow) staining of LIMK1 in some of the basal cells in the normal prostate (Mag. × 200). B) Representative images of prostate tumors of different grades. Upper panels: Weak staining of LIMK1 (yellow arrows) in grade 1 (TG1) and grade 2 (TG2) tumors (left two boxes); Strong nuclear and cytoplasmic staining of LIMK1 in cancerous areas (blue arrows) of grade 3 (TG3) and grade 4 (TG4) tumors (right two boxes). Lower panels: Left two boxes: Weak staining of MT1-MMP (yellow arrows) in grade 1 (TG1) and grade 2 (TG2) tumors; Right two boxes: Strong nuclear and cytoplasmic staining of MT1-MMP in tumor areas could be seen (blue arrows) in grade 3 (TG3) and grade 4(TG4) tumors (Mag. × 200). C) Graphical representation of the relative staining intensity of LIMK1 and MT1-MMP in low-grade (LG) and high-grade (HG) tumors. LGNS and HGNS: Very low to no staining.

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