Effect of LIMK1 on transcription activation of MT1-MMP. A) Relative luciferase activity in BPHLCA and BPHV cells transfected with MT1-MMP promoter luciferase constructs. B) Relative luciferase activity in PC3 cells transfected with MT1-MMP promoter luciferase construct alone or in combination with scrambled shRNA or LIMK1 shRNA expressing plasmids. Results show Mean ± SD of at least three separate experiments. *P = 0.0075 (BPHLCA vs. BPHV), **P = 0.004 (PC3 scr shRNA vs. PC3LIMK1 shRNA), ***P = 0.0005 (PC3 vs. PC3LIMK1 shRNA).