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Figure 4 | Molecular Cancer

Figure 4

From: Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer and stem cells and promotes cancer growth

Figure 4

Promoter DNA methylation pattern and Rhox5 mRNA expression level. ( A). DNA methylation status in Pd, Pp, and TSS regions in different cell types including ES, somatic cells, and cancer cells. Each column represented one CpG site and one row indicated separate clones picked for sequencing. Open and filled circles indicate individual unmethylated and methylated CpGs, respectively. (B). Correlation of Pd DNA methylation status versus gene transcription in 10 different cell types. Cell types are, NE: normal mammary epithelial cells MM3MG. Six cancer cell lines used are, EMT6, 4T1, P815, MOSEC, CT26 and MC38. -: non-detectable; +/-: extremely low; +: low; ++: moderate; +++: high.

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Molecular Cancer

ISSN: 1476-4598