Figure 6
From: New Topoisomerase I mutations are associated with resistance to camptothecin
Effects of SN38 on cell cycle distribution. A) Cell cycle profiles of SN38 sensitive and resistant HCT116 cell lines treated (T, red line) or not (NT, grey line) with 20 nM SN38 for 24 hours. B) Cell cycle distribution in SN38 sensitive HCT116-s cells and SN38 resistant HCT116-SN6, -S2, -SN50, -C8, -G7 cells with or without treatment with 20nM SN38. The percentages for each cell cycle phase are presented as the mean ± SD of at least 3 independent experiments.