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Figure 1 | Molecular Cancer

Figure 1

From: Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

Figure 1

Dysregulation of MCM7 in lung cancer tissues, and correlation of MCM7 expression to a negative outcome for NSCLC patients after surgical operation. (A) Overexpression of MCM7 in clinical lung cancer tissues [NSCLC (n = 6) and SCLC (n = 3)] compared with several normal tissues (lung, brain, colon, esophagus, eye, heart, liver, rectum, stomach, bladder and kidney) analyzed by quantitative real-time PCR. Statistical analysis was done using Kruskal-Wallis test; P < 0.0001: Mann Whitney U-test; *, P < 0.05; NS, not significant (P = 0.0528). (B) Representative cases for positive MCM7 expression in lung ADC, SCC tissues and normal lung tissues. Original magnification, ×100 and ×200. (C) Immunohistochemical analysis of MCM7 in various normal tissues. No significant staining was observed. Characteristics of each tissue were described in Additional file 12. (D) Kaplan-Meier estimates of overall survival time of patients with NSCLC (P = 0.0055, log-rank test).

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Molecular Cancer

ISSN: 1476-4598