Skip to main content
Figure 6 | Molecular Cancer

Figure 6

From: Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1

Figure 6

Inhibition of Rac1 differentially affects TGF-β1-mediated C-terminal domain phosphorylation of Smad2 and Smad3. PANC-1-dn Rac1 cells used in Fig. 3 were analysed along with wild type (wt) cells and empty vector (vector)-transduced control cells by immunoblotting for their ability to phosphorylate Smad2 (p-Smad2, upper panel) and Smad3 (p-Smad3, lower panel) in response to TGF-β1 stimulation (Smad3: 1 h, Smad2: as indicated in the figure). Total Smad levels (t-Smad) were detected as loading controls.

Back to article page

Molecular Cancer

ISSN: 1476-4598