Figure 6
From: Epigenetic reprogramming of breast cancer cells with oocyte extracts
Effect of epigenetic reprogramming on in vivo tumorigenicity. Macroscopic and microscopic analyses of tumour xenografts. (A) Macroscopic appearance of untreated (UN) and AOE-treated tumour xenografts (AOE) and relative tumour growth curves (* indicates P < 0.05). (B) Eosin-Haematoxylin staining of untreated tumour sections (black arrows: mitotic figures; Bar = 50 μm). (C) Number of mitotic figures for two independent tumours in untreated (UN) and AOE-treated xenografts (AOE) (* indicates P < 0.05). (D) Interstitial stroma present in AOE-treated tumours stained for collagen (blue staining; Bar = 50 μm).