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Table 2 In-vitro Survival of RT112 Human Bladder Cancer and Normal Diploid Human Fibroblasts

From: Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4

   

Cell Viability

 

Compound

Dose

Human Bladder Cancer

Normal Diploid Fibroblasts

I.

FPPRGPRPVQ

1.0 mM

+/-

+ +/-

II. (THR1)

PRGPRP

5.0 mM

- - -

+ + + + +

III.

PRGPR

5.0 mM

- - -

+ + +

IV.

RGPRP

5.0 mM

+/-

+ + +

V.

RGPR

5.0 mM

+ + +

+ + +

VI.

PRRPGP

5.0 mM

+ + +

+ + +

VII.

PEGPRP

5.0 mM

+ + +

+ + +

VIII.

PRGPEP

5.0 mM

+ + +

+ + +

IX.

PEGPEP

5.0 mM

+ + +

+ + +

  1. (+++ = same morphological appearance as untreated contros, --- = total morphological cell death. See Figure 2A for typical examples)