Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4

Table 3 In-vitro Survival of H460 Human Non-small Cell Lung Cancer and Normal Diploid Human Fibroblasts Following Exposure to Cyclic Non-Amphiphilic or Linear Amphiphilic Analogues of PRGPRP.

			Cell Viability
	Compound	Dose	Human Non-small Cell Lung Cancer	Normal Diploid Fibroblasts
X.	Cyc-[AAAGGGPRGPRPGGGAAA]	200 μM	+ + +	+ + +
XI.	Cyc-[GGGGGGPRGPRPGGGGGG]	200 μM	+ + +	+ + +
XII.	Cyc-GGGGGGPRGPRPGGGGGG]	200 μM	+ + +	+ + +
XIII.	Cyc-[AAGPGGPRGPRPGGPGAA]	200 μM	+ + +	+ + +
XIV.	Linear FPPRGPRPVKLALKLALK	200 μM	+ + +	+ + +
XV	Linear PRGPRPVALKLALKLAL	200 μM	+ + +	+ + +

ISSN: 1476-4598