Table 4 In-vitro Survival of H460 Human Non-small Cell Lung Cancer and Normal Diploid Human Fibroblasts Following Exposure to Cyclic Amphiphilic Analogues of PRGPRP.
| Â | Â | Â | Cell Viability | |
|---|---|---|---|---|
| Â | Compound | Dose | Human Non-small Cell Lung Cancer | Normal Diploid Fibroblasts |
XVI. (THR53) | Cyc-[FPPRGPRPVKLALKLALK] | 200 μM | _ _ _ | + + + |
XVII. (THR53C) | Cyc-[FPPRRPGPVKLALKLALK] | 200 μM | + + + | + + + |
XVIII. (THR54) | Cyc-[PRGPRPVALKLALKLAL] | 100 μM | _ _ _ | + + + |
XIX. (THR79) | Cyc-[PRGPRPvalklalklal] | 50 μM | _ _ _ | + + + |
XX. | Cyc-[PR(Me)GPRPVALKLALKLAL] | 200 μM | + +/- | N/D |
XXI. | Cyc-[PRGPR(Me)PVALKLALKLAL] | 200 μM | ++ + | N/D |
XII. | Cyc-[PR(Me)GPR(Me)PVALKLALKLAL] | 200 μM | + + + | N/D |