Figure 3

CCX771 blocks CXCL12-potentiated NC-37 cell TEM to CXCL13. NC-37 cell TEM to 300 nM CXCL13 in the presence of 10 nM CXCL12 in both wells was performed in the presence of a range of concentrations of CCX771 (green squares), CCX704 (red circles) or AMD3100 (blue diamonds). NC-37 cell TEM in the absence of chemokines (black square), presence of CXCL12 only (black circle) and presence of CXCL13 and CXCL12 (but absence of compounds, black diamond) are indicated on the left. The mean ± range of duplicate wells per treatment is shown. Representative of 3 independent experiments.