Skip to main content

Advertisement

Figure 5 | Molecular Cancer

Figure 5

From: Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin

Figure 5

Differential regulation of cisplatin-induced apoptosis and necrosis by DNA-PK and FACT. A. Regulation of cisplatin-induced apoptosis and necrosis by DNA-PKcs. DNA-PKcs and control shRNA-expressing A2780 cells were treated with 25 μg/ml cisplatin for 24 hrs and relative amounts of nucleosomes were quantified in lysates (apoptosis) and culture supernatants (necrosis). Comparison between cisplatin treated control and DNA-PKcs depleted cells is shown, p < 0.05. B. Regulation of cisplatin-induced apoptosis and necrosis by SSRP1. SSRP1 and control shRNA-expressing A2780 cells were treated and analysed as in (A). Comparison between cisplatin treated control and SSRP1 depleted cells, p < 0.01 (apoptosis) and p < 0.05 (necrosis) are shown.

Back to article page