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Figure 10 | Molecular Cancer

Figure 10

From: Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation

Figure 10

IGF-1 stimulates Erk and Akt activities and elevates cyclin D1 expression. A-B: (A) LM2 or (B) JF32 cells were cultured in serum-free media, with or without 2 ng/mL mIGF-1 or mEGF, and cell homogenates were probed for protein expression. C-E: densitometry from western blot replicates from LM2 and JF32 cell lines was combined, and presented as fold change (mean ± SEM) from untreated vehicle control lanes at each time point. * P < 0.05, ** P < 0.01 and *** P < 0.001 versus control (Veh -) cells at each time point by 2-way ANOVA.

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Molecular Cancer

ISSN: 1476-4598