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Figure 4 | Molecular Cancer

Figure 4

From: Stimulation of neoplastic mouse lung cell proliferation by alveolar macrophage-derived, insulin-like growth factor-1 can be blocked by inhibiting MEK and PI3K activation

Figure 4

Macrophage co-culture stimulated neoplastic proliferation can be blocked by combined kinase inhibition. A-B: Neoplastic (A) LM2 or (B) JF32 cells were cultured alone (-MØ, white bars) or with primary BAL macrophages (+MØ, black bars). Co-culture media was supplemented with 0.05% DMSO (vehicle), 5 μM U0126 (U0) and/or 10 μM LY294002 (LY). Proliferation was determined by MTS and mean + SD plotted as fold-change from vehicle control. Data was pooled from 3 independent experiments. * P < 0.05 and ** P < 0.001 versus-MØ control for each treatment by 2-way ANOVA.

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Molecular Cancer

ISSN: 1476-4598