3-10 kDa molecules in MØCM stimulate epithelial proliferation. Neoplastic LM2 cells were cultured for 72 hrs after the addition of fresh media (Control, white bars) or MØCM (+MØCM, black bars), separated by size (kDa) into the fractions indicated. Relative cell number was determined by MTS and mean + SD plotted as fold-change from control cultures, normalized for each size fraction. Data was pooled from n = 3 independent experiments. * P < 0.01 and ** P < 0.001 versus control within each fraction group, and # P < 0.01, ## P < 0.001 versus total (unfractionated) MØCM by 2-way ANOVA.