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Figure 6 | Molecular Cancer

Figure 6

From: Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression

Figure 6

Caspase-8 activation in MiTMAB treated cells occurs downstream of caspase-9/3 activation. G2/M synchronized HeLa-Bcl-2 cells were treated with MiTMABs and controls as described in the legend to Figure 5. Following an 8 h exposure to MiTMABs, lysates (prepared in duplicate) were immunoblotted for caspase-8. In contrast to HeLa cells (Figure 3), cleaved caspase-8 was not observed in HeLa-Bcl-2 cells treated with MiTMABs. Lysates prepared from UV treated HeLa and HeLa-Bcl-2 cells were used as a positive control. β-actin served as a loading control.

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