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Figure 5 | Molecular Cancer

Figure 5

From: Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells

Figure 5

SXR involvement in induction of irinotecan metabolism genes. A. Detection of SXR by western blot in LS180 and HepG2 cells after 48 h siRNA transfection. B. After 48 h siRNA transfection, cells were cultivated for 24 h in new medium and mRNA levels of the irinotecan metabolism genes were determined. Data represent percentage of mRNA levels after siRNA-SXR transfection compared to siRNA-control transfection. C. After 48 h siRNA transfection, cells were stimulated with 10 ng/ml SN-38 for 24 h and mRNA levels were determined. Data represent fold induction of mRNA levels compared to untreated cells.

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Molecular Cancer

ISSN: 1476-4598