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Figure 5 | Molecular Cancer

Figure 5

From: The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells

Figure 5

Inhibitory effect of Zt/f2 on 3H3-RON160 or HT-29 cell-mediated tumor growths. Induction of tumors in Balb/c mice by NIH3T3-RON160 cells (A) or in athymic nude mice by HT-29 cells (B) was detailed in Materials and methods. Tumor bearing mice were randomized into different groups (3 mice per group). Treatment of animals with Zt/f2, Zt/g4, or control mouse IgG at the defined dose and schedule as detailed in Materials and Methods. Mice were euthanized at day 32 in both experiments. The therapeutic effect of Zt/f2 on tumor growth was obtained by comparing tumor volumes among groups. Antibody injection is marked with arrows. Tumor growth index from control mice was set at 1.00 and used to compare the differences among groups.

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Molecular Cancer

ISSN: 1476-4598