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Figure 6 | Molecular Cancer

Figure 6

From: A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression

Figure 6

Deletion of BRCA2 abrogated the radiosensitizing effect of TAS106. Chinese hamster V79 and BRCA2-deficient V-C8 cells were pretreated with or without TAS106 (1 μM) for 6 h and its radiosensitizing effect was assessed by measuring clonogenic cell survival. Closed circle; X-irradiation for V79, open circle; X-irradiation + 1 μM TAS106 for V79, closed square; X-irradiation for V-C8, open square; X-irradiation + 1 μM TAS106 for V-C8. Data are expressed as mean ± SE of three experiments.

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Molecular Cancer

ISSN: 1476-4598