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Table 1 Summary of survival curves parameters

From: A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression

Cell line

TAS106

α

SERα

β

SERβ

D10

SERD10

 

(μM)

(Gy-1)

 

(Gy-2)

 

(Gy)

 

A549

0

0.04

-

0.032

-

7.88

-

 

0.5

0.04

1.00

0.033

1.03

7.77

1.01

 

0.75

0.12

3.00

0.033

1.03

6.73

1.17

 

1

0.12

3.00

0.061

1.91

5.24

1.50

Hep-2

0

0.21

-

0.013

-

7.49

-

 

0.1

0.41

1.95

0.017

1.31

4.70

1.59

V79

0

0.04

-

0.020

-

9.78

-

 

1

0.07

1.75

0.030

1.50

7.67

1.28

V-C8

0

0.33

-

0.024

-

5.09

-

 

1

0.42

1.27

0.020

0.83

4.51

1.13

  1. The data were fitted using the linear-quadratic model, SF = exp(-αD-βD2). The 10% lethal dose (D10) was calculated from the α and β values. The sensitizer enhancement ratio (SER) was calculated from the each values with or without TAS106.