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Figure 5 | Molecular Cancer

Figure 5

From: Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion

Figure 5

Manipulation of MUC1 dimerization using an engineered domain. A. Schematic of the mechanism of dimer formation/disruption by Fv ligands. B. Treatment of 293T MUC1-CFP-Fv cells with AP20187D/AP21998M and DSS. C. Densitometric analysis of dimer bands from B normalized to total MUC1. "No treatment" control refers to "DSS" only treatment from (B), and it set to one with the remaining conditions expressed as a ratio. D. Treatment of 293T MUC1-CFP cells with AP20187D/AP21998M and DSS. E. Densitometry of MUC1-CFP dimer bands from D normalized to total MUC1. "No treatment" control refers to "DSS" only treatment from (D) and is set to one with the remaining conditions expressed as a ratio. "D" and "M" indicate expected molecular weights of dimer and monomer, respectively. Whole cell lysates (WCL) are included as controls. Asterisk indicates a discrete population that does not overlap with any other population in the data set, p < 0.05.

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