Table 1 Histone transcripts show altered levels following silencing of CASP8AP2/FLASH

Fold change (Log ₂ ) siCASP8AP2.3

q values

siCASP8AP2.3

Fold change (Log ₂ ) siCASP8AP2.6

q values

siCASP8AP2.6

Narita et al

Shepard et al PAS seq ^#

NM_012115

CASP8AP2

chr6:90640368-90640427

A_23_P58898

-2.06

6.28E-15

-1.81

6.14E-13

-

-

NM_003548

HIST2H4A/

HIST2H4B

chr1:146617469-146617528

A_23_P436281

3.01

1.21E-20

2.61

4.73E-18

chr1 - 148098952-1

NM_003516

HIST2H2AA3/

chr1:146635701-146635760

A_23_P309381

3.80

9.00E-09

4.24

4.19E-10

Yes*

HIST2H2AA4

NM_003516

HIST2H2AA3/¹

chr1:146636178-146636234

A_23_P103981

3.83

3.55E-11

3.72

8.65E-11

HIST2H2AA4

NM_003528

HIST2H2BE

chr1:146669546-146669487

A_24_P148321

3.78

5.33E-13

3.63

1.93E-12

chr1-148122634-6, chr-148124269-1, chr1-148124357-1

NM_003528

HIST2H2BE

chr1:146670196-146670137

A_23_P149545

2.24

8.74E-14

2.39

7.62E-15

NM_003528

HIST2H2BE²

chr1:146671162-146671103

A_24_P156911

3.52

6.07E-19

3.49

7.82E-19

NM_003517

HIST2H2AC

chr1:146671911-146671970

A_24_P8721

3.17

3.73E-16

2.97

3.91E-15

chr1-148125568-4

NM_003517

HIST2H2AC

chr1:146671936-146671995

A_23_P301247

-1.90

8.19E-10

-2.02

1.36E-10

NM_175065

HIST2H2AB

chr1:146672317-146672258

A_24_P68631

3.88

1.18E-17

3.77

3.43E-17

NM_033445

HIST3H2A

chr1:224952044-224951985

A_23_P149301

3.10

1.82E-16

3.17

7.19E-17

NM_175055

HIST3H2BB

chr1:224952760-224952819

A_23_P332992

3.50

2.92E-16

3.42

6.04E-16

NM_003537

HIST1H3B

chr6:26139947-26139888

A_24_P174924

1.57

9.00E-06

1.12

1.50E-03

NM_003537

HIST1H3B

chr6:26139960-26139901

A_23_P93258

3.48

1.00E-13

3.31

5.69E-13

NM_003513

HIST1H2AB

chr6:26141499-26141440

A_24_P223384

1.93

3.63E-10

1.95

2.41E-10

NM_021062

HIST1H2BB

chr6:26151544-26151485

A_23_P111054

3.14

2.36E-15

2.93

2.72E-14

NM_005319

HIST1H1C

chr6:26164088-26164029

A_23_P122443

3.33

1.27E-13

3.40

5.92E-14

Yes

NM_003526

HIST1H2BC

chr6:26232021-26231962

A_23_P93180

3.36

5.81E-17

3.30

1.03E-16

NM_005321

HIST1H1E

chr6:26264907-26264966

A_23_P7976

3.35

1.45E-13

3.15

1.18E-12

chr6-26265322-1

NM_021063³

HIST1H2BD

chr6:26266453-26266512

A_24_P146211

3.87

1.47E-19

3.77

4.38E-19

Yes

ch6-26279217-1, ch6-26279551-20, chr6-26266834-7

NM_003523

HIST1H2BE

chr6:26292319-26292378

A_23_P30776

3.42

2.47E-16

3.44

1.72E-16

Yes

NM_003530

HIST1H3D

chr6:26305256-26305197

A_23_P219045

3.82

1.30E-14

3.83

1.10E-14

NM_003530

HIST1H3D

chr6:26305296-26305237

A_24_P217834

2.99

3.58E-13

3.09

1.01E-13

NM_021065

HIST1H2AD⁴

chr6:26307121-26307062

A_23_P428184

4.23

6.78E-16

4.21

6.99E-16

NM_003522

HIST1H2BF

chr6:26308082-26308141

A_23_P42178

3.44

3.50E-16

3.41

4.47E-16

Yes

NM_003518

HIST1H2BG

chr6:26324755-26324696

A_23_P167997

3.93

1.29E-20

3.78

6.51E-20

chr6-26324393-2

NM_021052

HIST1H2AE

chr6:26325533-26325592

A_23_P59045

4.32

9.87E-24

3.90

7.90E-22

Yes

chr6-26325683-13

NM_005320

HIST1H1D

chr6:26342737-26342678

A_24_P260639

3.59

1.39E-13

3.22

5.45E-12

NM_003540

HIST1H4F

chr6:26348797-26348856

A_23_P359540

2.78

1.14E-16

2.44

1.42E-14

NM_021018

HIST1H3F

chr6:26358626-26358567

A_23_P30799

3.36

2.65E-14

3.15

2.41E-13

chr6-26358379-1

NM_003524

HIST1H2BH

chr6:26360201-26360260

A_23_P366216

3.19

4.08E-16

3.04

2.19E-15

Yes

chr6-26360284-3

BC012185⁵

HIST1H3G

chr6:26377826-26377767

A_32_P794894

3.07

7.43E-30

3.54

8.23E-33

NM_003534

HIST1H3G

chr6:26379448-26379389

A_23_P42198

1.15

1.39E-04

1.27

3.34E-05

NM_003525

HIST1H2BI

chr6:26381354-26381413

A_23_P111041

3.51

7.27E-15

3.69

1.12E-15

Yes

chr6-26381629-2

NM_003543

HIST1H4H

chr6:26393535-26393476

A_23_P323685

4.03

1.13E-21

3.97

2.14E-21

NM_021058

HIST1H2BJ

chr6:27208356-27208297

A_24_P55148

3.81

3.69E-20

3.81

3.41E-20

NM_021064

HIST1H2AG

chr6:27209136-27209195

A_24_P303354

1.30

2.26E-10

1.08

3.92E-08

chr6-27209294-1

ch6-27210796-2

chr6-272111049-7

BC016677⁶

HIST1H2AG

chr6:27210269-27210328

A_24_P414658

4.19

9.07E-25

4.05

4.31E-24

NM_003495

HIST1H4I

chr6:27215204-27215263

A_24_P20873

1.75

1.69E-06

2.63

4.38E-11

NM_080593

HIST1H2BK

chr6:27221956-27221897

A_23_P145238

2.96

4.33E-10

3.34

1.12E-11

Yes

NM_080596

HIST1H2AH

chr6:27223225-27223284

A_23_P81859

1.67

1.41E-12

1.51

3.81E-11

NM_003519

HIST1H2BL

chr6:27883324-27883265

A_23_P8013

3.25

1.72E-14

3.10

8.91E-14

chr6-27883235-1

NM_003536

HIST1H3H

chr6:27886003-27886062

A_23_P333484

4.52

3.48E-25

4.05

4.51E-23

Yes

NM_021066

HIST1H2AJ/⁷

HIST1H2AI

chr6:27890225-27890166

A_23_P168014

2.30

6.42E-10

2.11

6.71E-09

chr6-27890034-2

NM_021066

HIST1H2AJ/

HIST1H2AI

chr6:27890432-27890373

A_24_P394510

2.44

5.52E-08

2.34

1.62E-07

NM_003521

HIST1H2BM

chr6:27890982-27891041

A_24_P3783

3.29

2.61E-14

3.39

8.13E-15

NM_003510

HIST1H2AK

chr6:27913767-27913708

A_24_P217848

1.56

1.98E-13

1.48

1.27E-12

NM_003520

HIST1H2BN⁸

chr6:27914524-27914583

A_23_P402081

3.46

6.89E-19

3.45

7.27E-19

chr6-27927954-1

NM_003511

HIST1H2AL

chr6:27941481-27941540

A_23_P363174

1.73

2.13E-11

1.97

2.31E-13

chr6-27941554-1

NM_005322

HIST1H1B

chr6:27942667-27942608

A_23_P250385

-1.35

8.17E-03

-1.61

2.22E-03

NM_003546

HIST1H4L

chr6:27948987-27948928

A_23_P70480

-1.46

3.81E-02

-1.59

3.28E-02

NM_003514

HIST1H2AM

chr6:27968545-27968486

A_32_P221799

4.10

3.17E-22

3.58

8.93E-20

NM_003514

HIST1H2AM

chr6:27968615-27968556

A_24_P86389

2.40

5.41E-15

2.35

1.10E-14

NM_003527

HIST1H2BO

chr6:27969567-27969626

A_23_P59069

3.25

1.97E-17

3.23

2.20E-17

⁹BC020884

HIST4H4

chr12:14813388-14813329

A_24_P261691

1.14

9.21E-09

1.68

5.34E-14

NM_002105

H2AFX

chr11:118469860-118469801

A_24_P38895

0.92

8.28E-06

0.82

6.13E-05

NM_177925

H2AFJ

chr12:14818894-14818953

A_24_P236003

1.08

1.95E-12

0.91

4.53E-10

NM_177925

H2AFJ

chr12:14819082-14819141

A_23_P204277

0.69

3.92E-06

0.80

1.51E-07