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Figure 1 | Molecular Cancer

Figure 1

From: A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line

Figure 1

3D comparison of STAT1 and STAT3 and of their DNA binding region. A: View of the superimposed 3D structure of STAT1 and STAT3 monomers created with the Chimera program, showing the DNA binding region. B and C: close-up views of the DNA binding regions of STAT1 (B) and STAT3 (C). Amino acids shown are those within a 5 Ã… distance from DNA; note that Thr 327 did not appear using this selection and was added. Arrows point to amino acids of STAT1 and STAT3 interacting differently with DNA.

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Molecular Cancer

ISSN: 1476-4598