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Table 1 Hydrogen bonds involved in the interaction of STAT1 and STAT3 with DNA

From: A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line

STAT1

STAT3

Nucleotide involved

Residue(s) involved

Nucleotide involved

Residue(s) involved

T 1005

Thr 427 (BB/Phos.)

T 1005

Val 432 (BB/Phos.)

T 1006

Lys 413 (BB/Phos.)

T 1006

Ser 465 (SC/Phos.)

 

Ser 459 (BB/Phos.)

T 1006

Arg 382 (SC/Phos.)

 

Arg 378 (BB/Phos.)

T 1006

Gln 469 (SC/Phos.)

 

Ser 459 (BB/Phos.)

T 1006

Ser 465 (SC/Phos.)

 

Gln 463 (BB/Phos.)

  

T 1007

Asn 460 (BB/Base)

T 1007

Asn 466 ND2(SC/Base)

  

T 1007

Arg 417 NH1 (SC/Phos.)

  

C 1008

Gln 344 NE2 (SC/Phos.)

  

C 1009

Gln 344 N (BB/Phos.)

C 1010

His 328 (SC/Phos.)

C 1010

Lys 340 (SC/Phos.)

  

C 1010

His 332 (SC/Phos.)

G 1011

Lys 567(SC/Phos.)

  

T 1012

Asn 460 (SC/Base)

T 1012

Asn 466 (SC/Base)

G 1017

Glu 421 (SC/Base)

  

C 1018

Thr 419 (BB/Phos.)

  
 

Thr 419 (BB/Phos.)

  

G 2002

Glu 421 (SC/Base)

  
 

Glu 421 (SC/Base)

  

T 2005

Thr 427 (BB/Phos.)

T 2005

Val 432 (BB/Phos.)

T 2006

Lys 413 (SC/Phos.)

T 2006

Ser 465 (SC/Phos.)

 

Arg 378 (SC/Phos.)

T 2006

Arg 382 (SC/Phos.)

 

Ser 459 (SC/Phos.)

T 2006

Ser 465 (SC/Phos.)

 

Arg 378 (SC/Phos.)

T 2006

Gln 469 (SC/Phos.)

T 2007

Asn 460 (SC/Base)

T 2007

Asn 466 (SC/Base)

 

Lys 413 (SC/BB)

T 2007

Arg 417 (SC/Phos.)

A 2008

Asn 460 (SC/Base)

A 2008

Gln 344 (SC/Phos.)

  

C 2009

Gln 344 (BB/Phos.)

G 2010

His 328 (SC/Phos.)

G 2010

Lys 340 (SC/Base)

  

G 2010

His 332 (SC/Phos.)

  

G 2010

Lys 340 (SC/Phos.)

G 2011

Lys 567 (BB/Phos.)

  

G 2012

Asn 460 (SC/Base)

G 2012

Asn 466 (SC/Base)

A 2013

Asn 460 (SC/Base)

  

G 2018

Glu 421 (SC/Phos.)

  
  1. The nucleotides that are involved in binding with STAT1 or STAT3 are listed. For clarity, the numbering used is the same as in reference [45] (see Figure 3). The following abbreviations were used for the atoms involved in hydrogen bonding: phospho-diester (Phos.) or base moiety (Base) for the nucleotides. BB stands for backbone and SC for side-chain for the proteins.