Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck

Table 1 Distribution of selected characteristics of the patient cohort (n = 1,292)

	Total		SPM-Free		SPM		P-values^c
Variable	No.	%	No.	%	No.	%
Total patients	1,292	100	1,172	100	120	100
Age
≤ median (57 years)	668	51.7	629	53.7	39	32.5	< 0.001
> median (57 years)	624	48.3	543	46.3	81	67.5
Sex
Male	981	75.9	887	75.7	94	78.3	0.518
Female	311	24.1	285	24.3	26	21.7
Ethnicity
Non-Hispanic White	1,093	84.6	999	85.2	94	78.3	0.050
Other	199	15.4	173	14.8	26	21.7
Smoking
Never	346	26.8	321	27.4	25	20.8	0.122
Ever	946	73.2	851	72.6	95	79.2
Alcohol
Never	337	26.1	310	26.4	27	22.5	0.348
Ever	955	73.9	862	73.6	93	77.5
Index Cancer Site
Oral cavity	420	32.5	382	32.6	38	31.7	0.320
Oropharynx	575	44.5	527	45.0	48	40.0
Larynx/Hypopharynx	297	23.0	263	22.4	34	28.3
Index Cancer Stage
I or II	327	25.3	295	25.0	32	26.7	0.720
III or IV	965	74.7	877	75.0	88	73.3
Treatment
Surgery only	230	17.8	209	17.8	21	17.5	0.894
Surgery + Adjuvant Tx^a	322	24.9	289	24.7	33	27.5
XRT^b	330	25.6	302	25.8	28	23.3
XRT + Chemotherapy	410	31.7	372	31.7	38	31.7

ISSN: 1476-4598