Figure 3

Loss of Hltf function enhances the formation of intestinal adenocarcinomas on Apc mutant background. (A) Haematoxylin-eosin staining of representative intestinal tumors developed in Apc^min/+ mice, showing the formation of a well-defined tubular adenoma within the lamina propria in these mice. (B) Two representative intestinal adenocarcimas from Hltf ^-/-/Apc^min/+ mice. Arrowhead indicates tumor invasion through the submucosa and into the muscularis propria. Immuno-staining with anti-β-catenin antibody also demonstrated that the invasive neoplatic glands contained high β-catenin activity as reflected by the nuclear accumulation of β-catenin signals (indicated by arrowheads)