Loss of HLTF function promotes intestinal carcinogenesis

Table 1 Summary of cytogenetic aberrations observed in colon tumors from Hltf ^-/-Apc^min/+ mice

Genotype of tumors	Metaphase Analyzed	Aneuploidy (%)^a	Translocations (%)	End-to-End Fusions (%)^b	Fragments (%)	Breaks (%)
Apc ^min/+	20	3 (15%)	0	0	0	0
Hltf ^-/- /Apc ^min/+	20	17 (85%)	7 (35%)	9 (45%)	16 (80%)	3 (15%)
Hltf ^-/- /Apc ^min/+	33	31 (93%)	10 (32%)	21 (63%)	15 (50%)	4 (20%)
Hltf ^-/- /Apc ^min/+	20	20 (100%)	3 (15%)	4 (20%)	1 (5%)	4 (20%)

^a Expressed as percentage of cells with other than 40 chromosomes (each Robertsonian fusion counted as two chromosomes).
^b Expressed as total number of end-to-end associated chromosomes per metaphase, including dicentric chromosomes, telomere associations and Robertsonian fusions

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