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Figure 4 | Molecular Cancer

Figure 4

From: Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype

Figure 4

A, ras-activity assay in pancreatic cancer cell lines Colo-357, Panc-1, T3M4, Su8686, 8988 T (all K-ras-mutated) and BxPC3 (wild-type K-ras); B, immunoprecipitation with an anti-SDC-2 antibody; lysates from BxPC3 and Su8686 cells (left panel); blotting with an anti-p120GAP antibody (right panel); C, immunoblot following SDC-2 RNAi: p120GAP, ras-activity (ras-GTP), total and phospho-Src (Tyr416), total and phospho-ERK; "Fold expression" has been calculated using densitometry of the immunoblots normalized to GAPDH; D, schematic SDC2 signaling in 1, non-transformed cells (WT ras) with "normal" ras activity and in 2, (malignant) transformed cells (ras-mutated) with ras overactivity.

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