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Figure 7 | Molecular Cancer

Figure 7

From: Nicotine, IFN-γ and retinoic acid mediated induction of MUC4 in pancreatic cancer requires E2F1 and STAT-1 transcription factors and utilize different signaling cascades

Figure 7

Schematic representation of signaling involved in MUC4 expression upon Nicotine, IFN-γ and Retinoic acid stimulation. Nicotine-mediated recruitment of E2F1 and STAT1 requires signaling through all the three pathways tested. In contrast, IFN-γ stimulation did not require PI3 kinase/Akt pathway to recruit E2F1 or STAT1, but ERK and Src seemed to contribute. In the case of RA stimulation, Akt and ERK pathways appeared to be important in upregulation of MUC4 expression.

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Molecular Cancer

ISSN: 1476-4598