From: Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin
 | Interaction with cisplatin | |||
---|---|---|---|---|
2008 | 2008 + FANCF | |||
Chemicals | FA-deficient | FA-proficient | ||
CI | Interpretation | CI | Interpretation | |
Bortezomib | 1.00 ± 0.05 | Additive | 0.88 ± 0.02 | Moderate synergism |
Lactacystin | 0.90 ± 0.05 | Slight synergism | 1.02 ± 0.05 | Additive |
MG132 | 1.13 ± 0.04 | Slight antagonism | 1.13 ± 0.05 | Slight antagonism |
ALLN | 1.17 ± 0.04 | Slight antagonism | 1.06 ± 0.09 | Additive |
5929407 | 1.10 ± 0.04 | Additive | 1.00 ± 0.04 | Additive |
Curcumin | 0.98 ± 0.02 | Additive | 1.06 ± 0.02 | Additive |
H-9 | 1.08 ± 0.04 | Additive | 0.98 ± 0.04 | Additive |
Gö6976 | 0.63 ± 0.04 | Synergism | 0.68 ± 0.03 | Synergism |
SB218078 | 0.90 ± 0.05 | Slight synergism | 0.77 ± 0.03 | Moderate synergism |
UCN-01 | 0.83 ± 0.03 | Moderate synergism | 0.66 ± 0.04 | Synergism |
Alsterpaullone | 1.05 ± 0.03 | Additive | 1.15 ± 0.03 | Slight antagonism |
Roscovitine | 0.98 ± 0.03 | Additive | 0.98 ± 0.03 | Additive |
Geldanamycin | 0.83 ± 0.04 | Moderate synergism | 0.38 ± 0.05 | Synergism |
17-AAG | 1.06 ± 0.10 | Additive | 0.87 ± 0.04 | Slight synergism |
CA-074-Me | 0.91 ± 0.03 | Additive | 0.78 ± 0.02 | Moderate synergism |
Chloroquine | 0.88 ± 0.05 | Slight synergism | 0.72 ± 0.05 | Moderate synergism |
Wortmannin | 1.08 ± 0.05 | Additive | 1.12 ± 0.05 | Slight antagonism |
DRB | 1.08 ± 0.04 | Additive | 0.97 ± 0.05 | Additive |
HNMPA-(AM)3 | 0.96 ± 0.02 | Additive | 0.91 ± 0.03 | Additive |
Puromycin | 1.08 ± 0.03 | Additive | 0.88 ± 0.04 | Slight synergism |
TPEN | 1.16 ± 0.08 | Slight antagonism | 1.13 ± 0.04 | Slight antagonism |
5656325 | 0.99 ± 0.03 | Additive | 1.05 ± 0.05 | Slight antagonism |
5315179 | 1.14 ± 0.09 | Slight antagonism | 0.94 ± 0.04 | Additive |
7012246 | 1.18 ± 0.05 | Slight antagonism | 0.87 ± 0.04 | Slight synergism |
5195243 | 1.22 ± 0.04 | Moderate antagonism | 1.02 ± 0.02 | Additive |
5373662 | 1.08 ± 0.04 | Additive | 0.90 ± 0.04 | Slight synergism |