Figure 3
From: Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1
Insertional mutagenesis using Sleeping Beauty transposons in Cadm1 mice. Cadm1 mice were bred onto a genetic background that allowed for Sleeping Beauty (SB) transposon-mediated insertional mutagenesis to occur in the soma, and placed on tumor watch. a. Cadm1 SB null mice died significantly faster than their wildtype SB littermates. b. This decreased survival of Cadm1 SB null mice was due to tumor formation, of a variety of types. c. Representative immunohistochemical images of (i) a lymphoma staining positive for CD3, (ii) a lymphoma staining positive for CD45R, (iii) and a leukemia staining positive for MPO. All magnifications are x400.