CXCR3 expression and localization in prostate tumor tissues. (A) CXCR3 localization in human normal prostate, localized and metastatic prostate cancer. The insets are at higher magnification to show the cellular localization of CXCR3 in the boxed areas. Pictures are representative among the samples. Bar: 100 μm. (B) and (C) CXCR3 was upregulated in human localized and metastatic prostate cancer tissue. (B) Box plot of CXCR3 expression in human normal prostate, localized and metastatic prostate cancer by percentage of CXCR3-positive cells (*P < 0.01). (C) Quantification of CXCR3 expression in paired normal and cancerous prostate samples (P < 0.02).