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Table 1 IC50 list of isoflavonoids tested on endothelial cell proliferation

From: The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth

 

Compound

IC50(μM)

1

3’,8-Dinitro-7-hydroxy-4-methoxyisoflavone

>50

2

7-Hydroxy-4-methoxy-3’,5’,8-trinitroisoflavone

45.9

3

4,7-Dihydroxy-3’,5’,8-trinitroisoflavone

>50

4

3’-Nitro-2,4,4’-trihydroxydeoxybenzoin

>50

5

2,4-Dihydroxy-4’-methoxy-5-nitrodeoxybenzion

>50

6

5,7-Dihydroxy-4’-nitroisoflavone

14.1

7

7-Hydroxy-4’-methoxy-8-nitroisoflavone

>50

8

3’-Nitro-5,7,4’-trihydroxyisoflavone

35.2

9

7,4’-Dihydroxy-3’-nitroisoflavone

42.3

10

5,7-Dihydroxy-2’-methyl-4’-nitroisoflavone

19.5

11

8,4’-Dinitro-7-hydroxyisoflavone

>50

12

4’-Amino-5,7-dihydroxyisoflavone

>50

13

8’-Amino-7-hydroxy-4’-methoxyisoflavone

31.7

14

3’-Amino-5,7,4’-trihydroxyisoflavone

24.8

15

3’-Amino-7,4’-dihydroxyisoflavone

37.5

16

4’-Amino-5,7-dihydroxy-2’-methylisoflavone

>50

17

4’,8-Diamino-7-hydroxyisoflavone

>50

18

8,4’-Diamino-7,5,dihydroxyisoflavone

>50

19

7,4’-Dihydroxy-8,5’-dinitroisoflavone

42.2

20

4’-methylequol

28

21

3’-methoxyequol

19

22

6-methoxyequol

3

23

6’-OH-ODMA

38

24

4’-O-methylequol

25

25

7’-Hydroxyenterolactone

>50

26

Pinoresinol

38

27

Luteolin

5

28

Genistein

5