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Figure 2 | Molecular Cancer

Figure 2

From: Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines

Figure 2

Axes 1 (horizontal) and 2 (vertical) of the unsupervised CIA for SKBR3 cell line data. A gene/TFBS frequency table produced with a PSSM threshold of 0.8 was used. Figure2(a) shows the projection of the cell line samples. The 0.1% DMSO treated samples (black 0 hr, red 2 hr, light blue 6 hr, light green 12 hr and orange 24 hr), are split from the 0.1 μM lapatinib treated samples (dark blue 6 hr, cyan 12 hr and dark green 24 hr) and the 1 μM lapatinib treated samples (purple 6 hr and pale blue 12 hr). The exception being the eight 0.1 μM lapatinib and 1 μM lapatinib treated samples at 2 hours post treatment coloured magenta and grey respectively. Figure,2(b) Shows the projection of the TFBS motifs. Motifs that are in the same orientation (direction from the origin) as a group of samples are associated with those samples.

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Molecular Cancer

ISSN: 1476-4598