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Table 3 Genes Selected for Taqman RT-PCR

From: Gene expression changes as markers of early lapatinib response in a panel of breast cancer cell lines

Gene Symbol

Gene Name

Key

Targeted by

CCND1

Cyclin D1

1,3

AHR/ARNT, PAX9, RAR/RXR

ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

2,3

OLF-1

FOXO3

Forkhead box protein O3

1,3

RAR/RXR

NR3C1

nuclear receptor sub family 3 group C member 1

2,3

AHR/ARNT, PAX3

RB1CC1

RB1 inducible coiled coil protein 1

3

ZNF143

ALDH3A2

aldehyde dehydrogenase 3 family member 2a

2+

 

CDKN1B

cyclin dependent kindase inhibitor 1B

2+

 

PIK3C3

phosphoinositide 3 kinase class 3

2+

 

AKT1

v-akt murine thymoma viral oncogene homolog 1

3

RAR/RXR

BID

BH3 interacting domain

2

 

E2F3

E2F transctription factor 3

1,3

AHR/ARNT, OLF-1, PAX9, ZNF143

eIF4E

eukaryotic translation initiation factor 4e

3

PAX3, RAR/RXR

FKBP4

Fk506 binding protein 4

2,3

ZNF143

MAPK9

mitogne-activated protein kinase 9

2

 

PARP2

poly (ADP-ribose) polymerase 2

2

 

PSMD13

proteasome 26 S subunit non-ATPase 13

2

 

SLC29A1

solute carrier family 29 member 1

2

 

TFPT

TCF3 (E2A) fusion partner

2,3

ZNF143

CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

2

 
  1. 1 denotes a highly differentially regulated gene (±2 fold across all 6 comparisons) 2 denotes a gene that was known to be associated with cancer, 3 denotes a gene was predicted to be targeted by one or more of the transcription factors. Those in bold were found to be consistently dysregulated in response to lapatinib in all 6 of the cell lines. + denotes that the gene was found to be differentially expressed in BT474 and SKBR3 cell lines but not in the additional four cell lines also tested