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Figure 2 | Molecular Cancer

Figure 2

From: Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

Figure 2

PHA-739358 induces apoptosis and cell cycle arrest. (A). Pt2 or UCSF02 cells were treated with increasing concentrations of PHA-739358 for 48 hours in triplicate. Apoptotic cells were identified by flow cytometry as Annexin V/PI double-positive. (B). BLQ1 Ph-positive or Ph-negative US6 cells were exposed to 1 μM PHA-739358 for 48 hours and cell cycle distribution was assessed by flow cytometry at different time points as indicated. (*p < 0.05, **p <0.001).

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