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Figure 5 | Molecular Cancer

Figure 5

From: Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib)

Figure 5

Monitoring of PHA-739358 treatment effect in vivo on molecular targets. Fully leukemic NSG mice transplanted with Pt2 Ph-positive ALL were treated with PHA-739358 (45 mg/kg, iv). Samples of one non-treated (−) and two drug-treated (+) mice are shown. Two hours after injection, spleen and bone marrow were collected. The expression of p-Tyr, p-histone H3 (Ser 10), p-Crkl, histone H3 and Crkl was assessed by Western blot. Bcr and Gapdh serve as a loading control.

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Molecular Cancer

ISSN: 1476-4598