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Table 3 Re-expression of chromosome 14q32 miRNAs following treatment with epigenetic modifiers

From: Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor

  Normal Human Melanocytes Melanoma Cell lines
Mel33B1 14PA Mel526 Mel624
5aza + PBA - + - + - + - + - +
Mir-127 70.6 61.4 UD UD 7.1 37.3 UD 9.5 UD UD
Mir-136 52 44.4 UD UD 7.9 30.8 UD UD UD UD
Mir-376a 100.1 75.4 UD UD UD 12.4 UD UD UD UD
Mir-376c 122.1 77.6 UD UD UD 10.4 UD UD UD UD
Mir-485-3p 12.7 18.4 UD 23.9 37.7 38.6 31.1 19.2 UD 16
  1. The expression levels of five chromosome-14q32 miRNAs in normal melanocytes and four melanoma cell lines as assessed by miRNA micro-array following treatment with epigenetic modifiers (10 μM 5-Aza and 3 mM PBA); UD-undetected. The miRNAs with significant differences between treatment and control are bolded