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Table 3 Re-expression of chromosome 14q32 miRNAs following treatment with epigenetic modifiers

From: Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor

 

Normal Human Melanocytes

Melanoma Cell lines

Mel33B1

14PA

Mel526

Mel624

5aza + PBA

-

+

-

+

-

+

-

+

-

+

Mir-127

70.6

61.4

UD

UD

7.1

37.3

UD

9.5

UD

UD

Mir-136

52

44.4

UD

UD

7.9

30.8

UD

UD

UD

UD

Mir-376a

100.1

75.4

UD

UD

UD

12.4

UD

UD

UD

UD

Mir-376c

122.1

77.6

UD

UD

UD

10.4

UD

UD

UD

UD

Mir-485-3p

12.7

18.4

UD

23.9

37.7

38.6

31.1

19.2

UD

16

  1. The expression levels of five chromosome-14q32 miRNAs in normal melanocytes and four melanoma cell lines as assessed by miRNA micro-array following treatment with epigenetic modifiers (10 μM 5-Aza and 3 mM PBA); UD-undetected. The miRNAs with significant differences between treatment and control are bolded