Skip to main content
Figure 6 | Molecular Cancer

Figure 6

From: Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells

Figure 6

Schematic representation of the combination effect of cisplatin and UV-C in human colorectal cancer cells. After UV-C exposure even at a low dose, cell surface EGFR is internalized. With time the internalized EGFR by UV-C recycles back to the cell membrane, but cisplatin blocks this recycling and induces EGFR degradation, resulting in cell cycle arrest.

Back to article page

Molecular Cancer

ISSN: 1476-4598