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Figure 1 | Molecular Cancer

Figure 1

From: Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model

Figure 1

Commonly upregulated genes between HCT116 cells in 3 DC and clinical CRC samples. (A) Differentially expressed genes between HCT116 and HKe3 cells grown in 3 DC for 6 days. Dots represent the corresponding score for each gene (red, the genes upregulated in HCT116 cells; blue, the genes upregulated in HKe3 cells). The green square represents the genes with a score of more than 10 (387 genes). (B) Differential expressions of the 387 genes detected in (A) between 12 human colorectal tumor specimens and 10 colonic mucosa specimens from the Hong dataset. Dots represent the corresponding score of each gene (red, the genes upregulated in CRC; blue, the genes upregulated in normal colonic mucosa). The green square represents the genes with a score more than three (25 genes). (C) The expression pattern of the 25 genes detected in (B) in colorectal tumor specimens and in normal colonic mucosa specimens from the Hong dataset.

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Molecular Cancer

ISSN: 1476-4598