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Figure 2 | Molecular Cancer

Figure 2

From: Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model

Figure 2

PDE4B is upregulated by oncogenic KRAS in 3 DC. (A) Differential expressions of PDE4 family members between HCT116 cells and HKe3 cells grown in 3 DC. Rows represent Affymetrix IDs, gene symbols and scores. Columns represent normalized expression levels of PDE4 family members. (B) mRNA expression levels for PDE4 family members in 3 DC. mRNA expression levels for PDE4 family members in HKe3 (black bar) and HCT116 (white bar) cells grown in 3 DC. *, P < 0.05; **, P < 0.01; n.s., not significant. (C) mRNA expression levels for PDE4B and PDE4D isoforms in 3 DC. mRNA expression levels for PDE4B in HKe3 (black bar) and HCT116 (white bar) cells grown in 3 DC. *, P < 0.01; n.s., not significant. (D) mRNA expression levels for PDE4B in 2 DC or 3 DC. mRNA expression levels for PDE4B in HKe3 (black bar), HCT116 (white bar) and e3-MKRas#14 (gray bar) cells grown in 2 DC or 3 DC. *, P < 0.05; **, P < 0.01; n.s., not significant.

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Molecular Cancer

ISSN: 1476-4598