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Figure 5 | Molecular Cancer

Figure 5

From: Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model

Figure 5

Induction of luminal apoptosis by PDE4B2 -shRNAs in HCT116 cells grown in 3 DC. (A) mRNA expression levels for PDE4B2 in 3 DC. *, P < 0.005. (B) The amount of cytoplasmic cAMP in HCT 116 cells grown in 2-D or 3-D culture. (C) The ratio of the 3-D structures containing apoptotic cells. *, P < 0.005. mRNA expression levels for PDE4B2 in HCT116 cells with control shRNA (black bar) and PDE4B2-shRNAs (white bar) grown in 3 DC.

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Molecular Cancer

ISSN: 1476-4598