The emerging role of histone lysine demethylases in prostate cancer

Table 2 List of KDM genes described as relevant for PCa. For gene aliases, see Table 1

GENE	ROLE IN PROSTATE CANCER	REF.
KDM1A	Oncogene, AR co-activator, associated with higher relapse risk	25-28
KDM2A	Putative tumor suppressor, reduced expression in PCa	41
KDM3A	Putative oncogene, overexpressed in PCa, AR co-activator	30, 33
KDM4A	Overexpressed in PCa	33
KDM4B	Overexpressed in PCa	33
KDM4C	Putative oncogene, overexpressed in CRPC, AR co-activator	30-32
KDM5B	Overexpressed in metastatic PCa, AR-co-activator	35
KDM5C	Putative oncogene, overexpressed in PCa, suppresses TGFB signalling	36
KDM6B	Putative oncogene, overexpressed in metastatic PCa	38
PHF8	Putative oncogene, overexpressed in PCa, mediates cell invasion	33

ISSN: 1476-4598