Skip to main content

Table 2 List of KDM genes described as relevant for PCa. For gene aliases, see Table 1

From: The emerging role of histone lysine demethylases in prostate cancer

GENE ROLE IN PROSTATE CANCER REF.
KDM1A Oncogene, AR co-activator, associated with higher relapse risk 25-28
KDM2A Putative tumor suppressor, reduced expression in PCa 41
KDM3A Putative oncogene, overexpressed in PCa, AR co-activator 30, 33
KDM4A Overexpressed in PCa 33
KDM4B Overexpressed in PCa 33
KDM4C Putative oncogene, overexpressed in CRPC, AR co-activator 30-32
KDM5B Overexpressed in metastatic PCa, AR-co-activator 35
KDM5C Putative oncogene, overexpressed in PCa, suppresses TGFB signalling 36
KDM6B Putative oncogene, overexpressed in metastatic PCa 38
PHF8 Putative oncogene, overexpressed in PCa, mediates cell invasion 33