The emerging role of histone lysine demethylases in prostate cancer

Table 3 List of KDM genes significantly up- or down-regulated in PCa clinical subtypes (MSKCC and Oncomine databases)

Gene	Clinical Variable	Gene expression	P value	Putative function	Oncomine
KDM1B	Overall Survival (OS)	Higher predicts shorter OS	0.0045	Oncogene	In agreement
KDM2B	PSA level at diagnosis	Higher predicts higher PSA	0.0070	Oncogene
	Gleason Score	Higher predicts higher grade	0.0001
	Lymph Node invasion	Higher predicts invasion	0.0002
	Metastasis	Higher predicts higher metastatic risk	3.09E-07
	Recurrence-Free Survival (RFS)	Higher predicts shorter RFS	0.0066
KDM3B	PSA level at diagnosis	Lower predicts higher PSA	0.0004	Oncosuppressor	In disagreement
	Gleason Score	Lower predicts higher grade	0.0066
KDM4C	Metastasis	Lower in non-metastatic tumors	0.0086	Oncogene	In agreement
KDM4D	Gleason Score	Higher predicts higher grade	0.0002	Oncogene
	Lymph Node invasion	Higher predicts invasion	0.0019
	Recurrence-Free Survival (RFS)	Higher predicts shorter RFS	0.0002
	Metastasis	Lower in non-metastatic tumors	0.001
KDM5A	Probability of recurrence after prostatectomy	Higher predicts higher probability	0.002	Oncogene
KDM5D	Gleason Score	Higher predicts lower grade	0.0035	Oncosuppressor	In agreement
	Lymph Node invasion	Lower predict invasion	0.0036
	Metastasis	Lower predicts higher metastatic risk	3.7E-5
	Probability of recurrence after prostatectomy	Lower predicts higher probability	0.0003
KDM7	Gleason Score	Higher predicts higher grade	0.0016	?
	Lymph Node invasion	Lower predicts invasion	0.0009
	Recurrence-Free Survival (RFS)	Higher predicts longer RFS	0.008

From the MSKCC database, we report all associations with p < 0.01, for the following clinical variables: PSA (prostate specific antigen) levels at diagnosis; Gleason score, based on prostatectomy; lymph node invasion; metastatic risk; recurrence free survival (or probability of recurrence) after prostatectomy; overall survival. Oncomine data are described as “in agreement” if they confirm the oncogene/oncosuppressor function deduced from the MSKCC database. Oncomine thresholds: p < 0.01; fold-change >2.0. Oncomine data are shown in Figure 2. For gene aliases, see Table 1.

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